Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome

Insulin is both a hormone regulating energy metabolism and a growth factor. We and others have shown that physiological doses of insulin initiate complex signals in primary human and mouse β-cells, but the functional significance of insulin's effects on this cell type remains unclear. In the pr...

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Detalhes bibliográficos
Main Authors: Johnson, James D., Bernal-Mizrachi, Ernesto, Alejandro, Emilyn U., Han, Zhiqiang, Kalynyak, Tatyana B., Li, Hong, Beith, Jennifer L., Gross, Julia, Warnock, Garth L., Townsend, R. Reid, Permutt, M. Alan, Polonsky, Kenneth S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748267/
https://ncbi.nlm.nih.gov/pubmed/17158802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604208103
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