Increased islet apoptosis in Pdx1(+/–) mice

Mice with 50% Pdx1, a homeobox gene critical for pancreatic development, had worsening glucose tolerance with age and reduced insulin release in response to glucose, KCl, and arginine from the perfused pancreas. Surprisingly, insulin secretion in perifusion or static incubation experiments in respon...

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Detalhes bibliográficos
Main Authors: Johnson, James D., Ahmed, Noreen T., Luciani, Dan S., Han, Zhiqiang, Tran, Hung, Fujita, Jun, Misler, Stanley, Edlund, Helena, Polonsky, Kenneth S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152933/
https://ncbi.nlm.nih.gov/pubmed/12697734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316537
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