Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

Mutations in pancreatic duodenal homeobox (PDX1) are linked to human type 2 diabetes and maturity-onset diabetes of the young type 4. Consistent with this, Pdx1-haploinsufficient mice develop diabetes. Both apoptosis and necrosis of β cells are mechanistically implicated in diabetes in these mice, b...

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Détails bibliographiques
Auteurs principaux: Fujimoto, Kei, Ford, Eric L., Tran, Hung, Wice, Burton M., Crosby, Seth D., Dorn, Gerald W., Polonsky, Kenneth S.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964996/
https://ncbi.nlm.nih.gov/pubmed/20978346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44011
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