Autophagy Regulates Pancreatic Beta Cell Death in Response to Pdx1 Deficiency and Nutrient Deprivation

There are three types of cell death; apoptosis, necrosis, and autophagy. The possibility that activation of the macroautophagy (autophagy) pathway may increase beta cell death is addressed in this study. Increased autophagy was present in pancreatic islets from Pdx1(+/−) mice with reduced insulin se...

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Detalhes bibliográficos
Main Authors: Fujimoto, Kei, Hanson, Piia T., Tran, Hung, Ford, Eric L., Han, Zhiqiang, Johnson, James D., Schmidt, Robert E., Green, Karen G., Wice, Burton M., Polonsky, Kenneth S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785695/
https://ncbi.nlm.nih.gov/pubmed/19654319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041616
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