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Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes
Mutations in pancreatic duodenal homeobox (PDX1) are linked to human type 2 diabetes and maturity-onset diabetes of the young type 4. Consistent with this, Pdx1-haploinsufficient mice develop diabetes. Both apoptosis and necrosis of β cells are mechanistically implicated in diabetes in these mice, b...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964996/ https://ncbi.nlm.nih.gov/pubmed/20978346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44011 |
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