Heat-Aggregated Noninfectious Influenza Virus Induces a More Balanced CD8(+)-T-Lymphocyte Immunodominance Hierarchy Than Infectious Virus

CD8(+)-T-cell (T(CD8+)) responses to infectious viruses are characterized by an immunodominance hierarchy in which the majority of T(CD8+) respond to one or a few immunodominant determinants, with a minority of T(CD8+) responding to a number of subdominant determinants. It is now well established th...

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Detalhes bibliográficos
Main Authors: Cho, Yunjung, Basta, Sameh, Chen, Weisan, Bennink, Jack R., Yewdell, Jonathan W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152137/
https://ncbi.nlm.nih.gov/pubmed/12663774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4679-4684.2003
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