Mice Deficient in Perforin, CD4(+) T Cells, or CD28-Mediated Signaling Maintain the Typical Immunodominance Hierarchies of CD8(+) T-Cell Responses to Influenza Virus

CD8 T-cell (T(CD8+)) responses elicited by viral infection demonstrate the phenomenon of immunodominance: the numbers of T(CD8+) responding to different viral peptides vary over a wide range in a reproducible manner for individuals with the same major histocompatibility complex class I alleles. To b...

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Detalhes bibliográficos
Main Authors: Chen, Weisan, Bennink, Jack R., Morton, Phillip A., Yewdell, Jonathan W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136568/
https://ncbi.nlm.nih.gov/pubmed/12239309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.20.10332-10337.2002
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