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Terminal Deoxynucleotidyl Transferase Establishes and Broadens Anti-Viral CD8(+) T Cell Immunodominance Hierarchies
The action of terminal deoxynucleotidyl transferase (TdT) on mouse T cell receptor (TCR) genes accounts for ∼ 90% of T cell repertoire diversity. We report that in TdT -/- mice, total T(CD8+) responses to influenza and vaccinia viruses are reduced by ∼ 30% relative to wt mice. We find that T(CD8+) r...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587314/ https://ncbi.nlm.nih.gov/pubmed/18566432 |
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