Terminal Deoxynucleotidyl Transferase Establishes and Broadens Anti-Viral CD8(+) T Cell Immunodominance Hierarchies

The action of terminal deoxynucleotidyl transferase (TdT) on mouse T cell receptor (TCR) genes accounts for ∼ 90% of T cell repertoire diversity. We report that in TdT -/- mice, total T(CD8+) responses to influenza and vaccinia viruses are reduced by ∼ 30% relative to wt mice. We find that T(CD8+) r...

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Main Authors: Haeryfar, S.M. Mansour, Hickman, Heather D., Irvine, Kari R., Tscharke, David C., Bennink, Jack R., Yewdell, Jonathan W.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587314/
https://ncbi.nlm.nih.gov/pubmed/18566432
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