Alteration of Escherichia coli Topoisomerase IV to Novobiocin Resistance

DNA gyrase and topoisomerase IV (topo IV) are the two essential type II topoisomerases of Escherichia coli. Gyrase is responsible for maintaining negative supercoiling of the bacterial chromosome, whereas topo IV's primary role is in disentangling daughter chromosomes following DNA replication. Coum...

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Bibliografiska uppgifter

I publikationen:	Antimicrob Agents Chemother
Huvudupphov:	Hardy, Christine D., Cozzarelli, Nicholas R.
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	American Society for Microbiology (ASM) 2003
Ämnen:	Mechanisms of Action: Physiological Effects
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149342/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604525/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.3.941-947.2003
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