Alteration of Escherichia coli Topoisomerase IV to Novobiocin Resistance

DNA gyrase and topoisomerase IV (topo IV) are the two essential type II topoisomerases of Escherichia coli. Gyrase is responsible for maintaining negative supercoiling of the bacterial chromosome, whereas topo IV's primary role is in disentangling daughter chromosomes following DNA replication....

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Detalles Bibliográficos
Main Authors: Hardy, Christine D., Cozzarelli, Nicholas R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC149342/
https://ncbi.nlm.nih.gov/pubmed/12604525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.3.941-947.2003
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