Topoisomerase IV is a target of quinolones in Escherichia coli.

We have demonstrated that, in Escherichia coli, quinolone antimicrobial agents target topoisomerase IV (topo IV). The inhibition of topo IV becomes apparent only when gyrase is mutated to quinolone resistance. In such mutants, these antibiotics caused accumulation of replication catenanes, which is...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Khodursky, A B, Zechiedrich, E L, Cozzarelli, N R
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40490/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524852/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11801
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