Topoisomerase IV is a target of quinolones in Escherichia coli.
We have demonstrated that, in Escherichia coli, quinolone antimicrobial agents target topoisomerase IV (topo IV). The inhibition of topo IV becomes apparent only when gyrase is mutated to quinolone resistance. In such mutants, these antibiotics caused accumulation of replication catenanes, which is...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40490/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524852/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11801 |
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