Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.

The random insertion of transgenes into the genomic DNA of mice usually leads to widely variable levels of expression in individual founder lines. To study the mechanisms that cause variegation, we designed a transgene that we expected to variegate, which consisted of a beta-globin locus control reg...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Graubert, T A, Hug, B A, Wesselschmidt, R, Hsieh, C L, Ryan, T M, Townes, T M, Ley, T J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147660/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.2849
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