Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.

The random insertion of transgenes into the genomic DNA of mice usually leads to widely variable levels of expression in individual founder lines. To study the mechanisms that cause variegation, we designed a transgene that we expected to variegate, which consisted of a beta-globin locus control reg...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Graubert, T A, Hug, B A, Wesselschmidt, R, Hsieh, C L, Ryan, T M, Townes, T M, Ley, T J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147660/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.2849
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