Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.

The random insertion of transgenes into the genomic DNA of mice usually leads to widely variable levels of expression in individual founder lines. To study the mechanisms that cause variegation, we designed a transgene that we expected to variegate, which consisted of a beta-globin locus control reg...

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Bibliografske podrobnosti

izdano v:	Nucleic Acids Res
Principais autores:	Graubert, T A, Hug, B A, Wesselschmidt, R, Hsieh, C L, Ryan, T M, Townes, T M, Ley, T J
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 1998
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147660/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.2849
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