Activated Cdc42/Rac reconstitutes FcɛRI-mediated Ca(2+) mobilization and degranulation in mutant RBL mast cells

Antigen stimulation of mast cells via FcɛRI, the high-affinity receptor for IgE, triggers a signaling cascade that requires Ca(2+) mobilization for exocytosis of secretory granules during an allergic response. This study investigates critical signaling components by using mutant RBL mast cells that...

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Hauptverfasser: Hong-Geller, Elizabeth, Holowka, David, Siraganian, Reuben P., Baird, Barbara, Cerione, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC14724/
https://ncbi.nlm.nih.gov/pubmed/11158610
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