Activated Cdc42/Rac reconstitutes FcɛRI-mediated Ca(2+) mobilization and degranulation in mutant RBL mast cells

Antigen stimulation of mast cells via FcɛRI, the high-affinity receptor for IgE, triggers a signaling cascade that requires Ca(2+) mobilization for exocytosis of secretory granules during an allergic response. This study investigates critical signaling components by using mutant RBL mast cells that...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hong-Geller, Elizabeth, Holowka, David, Siraganian, Reuben P., Baird, Barbara, Cerione, Richard A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14724/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.98.3.1154
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