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Phosphorylation of Tyr342 in the Linker Region of Syk Is Critical for FcɛRI Signaling in Mast Cells

The linker region of Syk and ZAP70 tyrosine kinases plays an important role in regulating their function. There are three conserved tyrosines in this linker region; Tyr317 of Syk and its equivalent residue in ZAP70 were previously shown to negatively regulate the function of Syk and ZAP70. Here we s...

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Bibliografiske detaljer
Main Authors: Zhang, Juan, Berenstein, Elsa, Siraganian, Reuben P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC134060/
https://ncbi.nlm.nih.gov/pubmed/12417718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8144-8154.2002
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