Importance of the N-Distal AP-2 Binding Element in Nef for Simian Immunodeficiency Virus Replication and Pathogenicity in Rhesus Macaques

Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity attenuate viral replication in acutely infected rhesus macaques, but changes selected later in infection fully restore Nef function (A. J. Iafrate et al., J. Virol. 74:9836-9844, 2000). To further ev...

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Hauptverfasser: Brenner, Matthias, Münch, Jan, Schindler, Michael, Wildum, Steffen, Stolte, Nicole, Stahl-Hennig, Christiane, Fuchs, Dietmar, Mätz-Rensing, Kerstin, Franz, Monika, Heeney, Jonathan, Ten Haaft, Peter, Swigut, Tomek, Hrecka, Katarzyna, Skowronski, Jacek, Kirchhoff, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472002/
https://ncbi.nlm.nih.gov/pubmed/16611907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4469-4481.2006
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