Importance of the N-Distal AP-2 Binding Element in Nef for Simian Immunodeficiency Virus Replication and Pathogenicity in Rhesus Macaques

Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity attenuate viral replication in acutely infected rhesus macaques, but changes selected later in infection fully restore Nef function (A. J. Iafrate et al., J. Virol. 74:9836-9844, 2000). To further ev...

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Hlavní autoři: Brenner, Matthias, Münch, Jan, Schindler, Michael, Wildum, Steffen, Stolte, Nicole, Stahl-Hennig, Christiane, Fuchs, Dietmar, Mätz-Rensing, Kerstin, Franz, Monika, Heeney, Jonathan, Ten Haaft, Peter, Swigut, Tomek, Hrecka, Katarzyna, Skowronski, Jacek, Kirchhoff, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472002/
https://ncbi.nlm.nih.gov/pubmed/16611907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4469-4481.2006
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