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Importance of the N-Distal AP-2 Binding Element in Nef for Simian Immunodeficiency Virus Replication and Pathogenicity in Rhesus Macaques

Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity attenuate viral replication in acutely infected rhesus macaques, but changes selected later in infection fully restore Nef function (A. J. Iafrate et al., J. Virol. 74:9836-9844, 2000). To further ev...

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Bibliografiske detaljer
Main Authors: Brenner, Matthias, Münch, Jan, Schindler, Michael, Wildum, Steffen, Stolte, Nicole, Stahl-Hennig, Christiane, Fuchs, Dietmar, Mätz-Rensing, Kerstin, Franz, Monika, Heeney, Jonathan, Ten Haaft, Peter, Swigut, Tomek, Hrecka, Katarzyna, Skowronski, Jacek, Kirchhoff, Frank
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472002/
https://ncbi.nlm.nih.gov/pubmed/16611907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4469-4481.2006
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