Importance of the N-Distal AP-2 Binding Element in Nef for Simian Immunodeficiency Virus Replication and Pathogenicity in Rhesus Macaques

Point mutations in SIVmac239 Nef disrupting CD4 downmodulation and enhancement of virion infectivity attenuate viral replication in acutely infected rhesus macaques, but changes selected later in infection fully restore Nef function (A. J. Iafrate et al., J. Virol. 74:9836-9844, 2000). To further ev...

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Detalhes bibliográficos
Main Authors: Brenner, Matthias, Münch, Jan, Schindler, Michael, Wildum, Steffen, Stolte, Nicole, Stahl-Hennig, Christiane, Fuchs, Dietmar, Mätz-Rensing, Kerstin, Franz, Monika, Heeney, Jonathan, Ten Haaft, Peter, Swigut, Tomek, Hrecka, Katarzyna, Skowronski, Jacek, Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472002/
https://ncbi.nlm.nih.gov/pubmed/16611907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4469-4481.2006
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