Simian Immunodeficiency Virus Containing Mutations in N-Terminal Tyrosine Residues and in the PxxP Motif in Nef Replicates Efficiently in Rhesus Macaques

SIVmac Nef contains two N-terminal tyrosines that were proposed to be part of an SH2-ligand domain and/or a tyrosine-based endocytosis signal and a putative SH3-ligand domain (P(104)xxP(107)). In the present study, we investigated the effects of combined mutations in these tyrosine and proline resid...

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Detalhes bibliográficos
Main Authors: Carl, Silke, Iafrate, A. John, Lang, Sabine M., Stolte, Nicole, Stahl-Hennig, Christiane, Mätz-Rensing, Kerstin, Fuchs, Dietmar, Skowronski, Jacek, Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC111930/
https://ncbi.nlm.nih.gov/pubmed/10756028
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