Simian Immunodeficiency Virus Containing Mutations in N-Terminal Tyrosine Residues and in the PxxP Motif in Nef Replicates Efficiently in Rhesus Macaques

SIVmac Nef contains two N-terminal tyrosines that were proposed to be part of an SH2-ligand domain and/or a tyrosine-based endocytosis signal and a putative SH3-ligand domain (P(104)xxP(107)). In the present study, we investigated the effects of combined mutations in these tyrosine and proline resid...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Carl, Silke, Iafrate, A. John, Lang, Sabine M., Stolte, Nicole, Stahl-Hennig, Christiane, Mätz-Rensing, Kerstin, Fuchs, Dietmar, Skowronski, Jacek, Kirchhoff, Frank
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4155-4164.2000
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