Efficient Class I Major Histocompatibility Complex Down-Regulation by Simian Immunodeficiency Virus Nef Is Associated with a Strong Selective Advantage in Infected Rhesus Macaques

Substitution of Y223F disrupts the ability of simian immunodeficiency virus (SIV) Nef to down-modulate major histocompatibility complex (MHC) class I from the cell surface but has no effect on other Nef functions, such as down-regulation of CD4, CD28, and CD3 cell surface expression or stimulation o...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Münch, Jan, Stolte, Nicole, Fuchs, Dietmar, Stahl-Hennig, Christiane, Kirchhoff, Frank
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114633/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11581427/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.21.10532-10536.2001
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