Efficient Class I Major Histocompatibility Complex Down-Regulation by Simian Immunodeficiency Virus Nef Is Associated with a Strong Selective Advantage in Infected Rhesus Macaques

Substitution of Y223F disrupts the ability of simian immunodeficiency virus (SIV) Nef to down-modulate major histocompatibility complex (MHC) class I from the cell surface but has no effect on other Nef functions, such as down-regulation of CD4, CD28, and CD3 cell surface expression or stimulation o...

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Autors principals: Münch, Jan, Stolte, Nicole, Fuchs, Dietmar, Stahl-Hennig, Christiane, Kirchhoff, Frank
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC114633/
https://ncbi.nlm.nih.gov/pubmed/11581427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.21.10532-10536.2001
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