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High efficiency of site-directed mutagenesis mediated by a single PCR product.

We describe a highly efficient procedure for site-specific mutagenesis of double-stranded plasmids. The method relies on a single PCR primer which incorporates both the mutations at the selection site and the desired single base substitutions at the mutant site. This primer is annealed to the denatu...

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Autores principales: Chen, X, Liu, W, Quinto, I, Scala, G
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC146466/
https://ncbi.nlm.nih.gov/pubmed/9016615
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