Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1

Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte (CTL) recognition is a major challenge for vaccine design. However, recent studies suggest that CTL escape may carry a sufficient cost to viral replicative capacity to facilitate subsequent immune control of a now at...

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Autors principals: Martinez-Picado, Javier, Prado, Julia G., Fry, Elizabeth E., Pfafferott, Katja, Leslie, Alasdair, Chetty, Senica, Thobakgale, Christina, Honeyborne, Isobel, Crawford, Hayley, Matthews, Philippa, Pillay, Tilly, Rousseau, Christine, Mullins, James I., Brander, Christian, Walker, Bruce D., Stuart, David I., Kiepiela, Photini, Goulder, Philip
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440414/
https://ncbi.nlm.nih.gov/pubmed/16537629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3617-3623.2006
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