Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection

HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduc...

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Main Authors: Crawford, Hayley, Prado, Julia G., Leslie, Alasdair, Hué, Stéphane, Honeyborne, Isobella, Reddy, Sharon, van der Stok, Mary, Mncube, Zenele, Brander, Christian, Rousseau, Christine, Mullins, James I., Kaslow, Richard, Goepfert, Paul, Allen, Susan, Hunter, Eric, Mulenga, Joseph, Kiepiela, Photini, Walker, Bruce D., Goulder, Philip J. R.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2007
נושאים:
Pathogenesis and Immunity
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951305/
https://ncbi.nlm.nih.gov/pubmed/17507468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00465-07
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