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Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

O-linked N-acetylglucosamine (O-GlcNAc) modification of specific serines/threonines on intracellular proteins in higher eukaryotes has been shown to directly regulate important processes such as the cell cycle, insulin sensitivity and transcription. The structure, molecular mechanisms of catalysis,...

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Autors principals: Rao, Francesco V, Dorfmueller, Helge C, Villa, Fabrizio, Allwood, Matthew, Eggleston, Ian M, van Aalten, Daan M F
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440316/
https://ncbi.nlm.nih.gov/pubmed/16541109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601026
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