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Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis
O-linked N-acetylglucosamine (O-GlcNAc) modification of specific serines/threonines on intracellular proteins in higher eukaryotes has been shown to directly regulate important processes such as the cell cycle, insulin sensitivity and transcription. The structure, molecular mechanisms of catalysis,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1440316/ https://ncbi.nlm.nih.gov/pubmed/16541109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601026 |
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