T-Cell Receptor:CD3 Down-Regulation Is a Selected In Vivo Function of Simian Immunodeficiency Virus Nef but Is Not Sufficient for Effective Viral Replication in Rhesus Macaques

We investigated the function of severely truncated simian immunodeficiency virus (SIV) Nef proteins (tNef) in vitro and in vivo. These variants emerged in rhesus monkeys infected with SIVmac239 containing a 152-bp deletion in the nef-unique region and have been suggested to enhance SIV virulence (E....

Popoln opis

Bibliografske podrobnosti

izdano v:	J Virol
Principais autores:	Münch, Jan, Janardhan, Ajit, Stolte, Nicole, Stahl-Hennig, Christiane, ten Haaft, Peter, Heeney, Jonathan L., Swigut, Tomek, Kirchhoff, Frank, Skowronski, Jacek
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2002
Teme:	Pathogenesis and Immunity
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136863/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12414978/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.23.12360-12364.2002
Oznake:	Označite Brez oznak, prvi označite!