T-Cell Receptor:CD3 Down-Regulation Is a Selected In Vivo Function of Simian Immunodeficiency Virus Nef but Is Not Sufficient for Effective Viral Replication in Rhesus Macaques

We investigated the function of severely truncated simian immunodeficiency virus (SIV) Nef proteins (tNef) in vitro and in vivo. These variants emerged in rhesus monkeys infected with SIVmac239 containing a 152-bp deletion in the nef-unique region and have been suggested to enhance SIV virulence (E....

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Main Authors: Münch, Jan, Janardhan, Ajit, Stolte, Nicole, Stahl-Hennig, Christiane, ten Haaft, Peter, Heeney, Jonathan L., Swigut, Tomek, Kirchhoff, Frank, Skowronski, Jacek
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136863/
https://ncbi.nlm.nih.gov/pubmed/12414978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.23.12360-12364.2002
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