T-Cell Receptor:CD3 Down-Regulation Is a Selected In Vivo Function of Simian Immunodeficiency Virus Nef but Is Not Sufficient for Effective Viral Replication in Rhesus Macaques

We investigated the function of severely truncated simian immunodeficiency virus (SIV) Nef proteins (tNef) in vitro and in vivo. These variants emerged in rhesus monkeys infected with SIVmac239 containing a 152-bp deletion in the nef-unique region and have been suggested to enhance SIV virulence (E....

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Pubblicato in:	J Virol
Autori principali:	Münch, Jan, Janardhan, Ajit, Stolte, Nicole, Stahl-Hennig, Christiane, ten Haaft, Peter, Heeney, Jonathan L., Swigut, Tomek, Kirchhoff, Frank, Skowronski, Jacek
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136863/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12414978/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.23.12360-12364.2002
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