Fluconazole Treatment Is Effective against a Candida albicans erg3/erg3 Mutant In Vivo Despite In Vitro Resistance

Candida albicans ERG3 encodes a sterol C5,6-desaturase which is essential for synthesis of ergosterol. Defective sterol C5,6 desaturation has been considered to be one of the azole resistance mechanisms in this species. However, the clinical relevance of this resistance mechanism is still unclear. I...

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Autors principals: Miyazaki, Taiga, Miyazaki, Yoshitsugu, Izumikawa, Koichi, Kakeya, Hiroshi, Miyakoshi, Shunichi, Bennett, John E., Kohno, Shigeru
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366932/
https://ncbi.nlm.nih.gov/pubmed/16436713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.580-586.2006
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