ERG3-Encoding Sterol C5,6-DESATURASE in Candida albicans Is Required for Virulence in an Enterically Infected Invasive Candidiasis Mouse Model

Gastrointestinal colonization by Candida species is considered the main source of candidemia. The ERG3 gene in Candida albicans encodes a sterol C5,6-desaturase, which is essential for ergosterol biosynthesis. Although ERG3 inactivation shows reduced virulence in mouse models of disseminated candidi...

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Veröffentlicht in:Pathogens
Hauptverfasser: Hirayama, Tatsuro, Miyazaki, Taiga, Sumiyoshi, Makoto, Ashizawa, Nobuyuki, Takazono, Takahiro, Yamamoto, Kazuko, Imamura, Yoshifumi, Izumikawa, Koichi, Yanagihara, Katsunori, Kohno, Shigeru, Mukae, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7823479/
https://ncbi.nlm.nih.gov/pubmed/33396406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens10010023
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