Fluconazole Treatment Is Effective against a Candida albicans erg3/erg3 Mutant In Vivo Despite In Vitro Resistance

Candida albicans ERG3 encodes a sterol C5,6-desaturase which is essential for synthesis of ergosterol. Defective sterol C5,6 desaturation has been considered to be one of the azole resistance mechanisms in this species. However, the clinical relevance of this resistance mechanism is still unclear. I...

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Autori principali: Miyazaki, Taiga, Miyazaki, Yoshitsugu, Izumikawa, Koichi, Kakeya, Hiroshi, Miyakoshi, Shunichi, Bennett, John E., Kohno, Shigeru
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366932/
https://ncbi.nlm.nih.gov/pubmed/16436713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.580-586.2006
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