Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases

Vascular endothelial growth factor (VEGF) signaling is critical to the processes of angiogenesis and tumor growth. Here, evidence is presented for VEGF stimulation of sphingosine kinase (SPK) that affects not only endothelial cell signaling but also tumor cells expressing VEGF receptors. VEGF or pho...

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Bibliographic Details
Main Authors: Shu, Xiaodong, Wu, Weicheng, Mosteller, Raymond D., Broek, Daniel
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC134718/
https://ncbi.nlm.nih.gov/pubmed/12391145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.22.7758-7768.2002
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