Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells

The transcription factor T-bet (Tbx21) plays a major role in adaptive immunity and is required for optimal IFN-γ production by DCs. Here we demonstrate an essential function for T-bet in DCs in controlling inflammatory arthritis. We show that collagen antibody–induced arthritis (CAIA), a model of hu...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wang, Jingsong, Fathman, John W., Lugo-Villarino, Geanncarlo, Scimone, Lucila, von Andrian, Ulrich, Dorfman, David M., Glimcher, Laurie H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2006
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326147/
https://ncbi.nlm.nih.gov/pubmed/16410834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26631
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