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The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells
Treatment with synthetic oligodeoxynucleotides containing CpG motifs (CpG ODNs) is remarkably protective against otherwise lethal infection. Here, we describe an essential role for the transcription factor T-bet in mediating the protective function of CpG ODNs. Loss of T-bet in conventional CD11c(hi...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1201626/ https://ncbi.nlm.nih.gov/pubmed/16135562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506638102 |
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