T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells

IFN-γ is well known as the signature cytokine of CD4(+) T helper 1, CD8(+), and natural killer cells, but recent studies demonstrate that antigen-presenting cells, in particular dendritic cells (DCs), are another potent source for this proinflammatory cytokine. T-bet, a transcription factor that con...

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Bibliographic Details
Main Authors: Lugo-Villarino, Geanncarlo, Maldonado-López, Roberto, Possemato, Richard, Peñaranda, Cristina, Glimcher, Laurie H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC164659/
https://ncbi.nlm.nih.gov/pubmed/12802010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1332767100
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