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Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
The transcription factor T-bet (Tbx21) plays a major role in adaptive immunity and is required for optimal IFN-γ production by DCs. Here we demonstrate an essential function for T-bet in DCs in controlling inflammatory arthritis. We show that collagen antibody–induced arthritis (CAIA), a model of hu...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1326147/ https://ncbi.nlm.nih.gov/pubmed/16410834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26631 |
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