Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13

Tissue remodeling with fibrosis is a predominant pathophysiological mechanism of many human diseases. Systemic sclerosis is a rare, often lethal, disorder of unknown etiology manifested by dermal fibrosis (scleroderma) and excessive connective tissue deposition in internal organs. Currently, there a...

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Main Authors: Aliprantis, Antonios O., Wang, Jingsong, Fathman, John W., Lemaire, Raphael, Dorfman, David M., Lafyatis, Robert, Glimcher, Laurie H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815266/
https://ncbi.nlm.nih.gov/pubmed/17307869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700021104
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