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Augmenting neurotransmitter release by enhancing the apparent Ca(2+) affinity of synaptotagmin 1

Synaptotagmin 1 likely acts as a Ca(2+) sensor in neurotransmitter release by Ca(2+)-binding to its two C2 domains. This notion was strongly supported by the observation that a mutation in the C2A domain causes parallel decreases in the apparent Ca(2+) affinity of synaptotagmin 1 and in the Ca(2+) s...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rhee, J.-S., Li, L. Y., Shin, O.-H., Rah, J.-C., Rizo, J., Südhof, T. C., Rosenmund, C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1311909/
https://ncbi.nlm.nih.gov/pubmed/16352718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509153102
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