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Differential but convergent functions of Ca(2+) binding to synaptotagmin-1 C(2) domains mediate neurotransmitter release
Neurotransmitter release is triggered by cooperative Ca(2+)-binding to the Ca(2+)-sensor protein synaptotagmin-1. Synaptotagmin-1 contains two C2 domains, referred to as the C2A and C2B domains, that bind Ca(2+) with similar properties and affinities. However, Ca(2+) binding to the C2A domain is not...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752550/ https://ncbi.nlm.nih.gov/pubmed/19805322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908798106 |
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