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Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C(2)A domain in asynchronous neurotransmitter release
Synaptotagmins (Syts) act as Ca(2+) sensors in neurotransmitter release by virtue of Ca(2+)-binding to their two C(2) domains, but their mechanisms of action remain unclear. Puzzlingly, Ca(2+)-binding to the C(2)B domain appears to dominate Syt1 function in synchronous release, whereas Ca(2+)-bindin...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635908/ https://ncbi.nlm.nih.gov/pubmed/28923929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710708114 |
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