Stress-induced decrease in TRAF2 stability is mediated by Siah2

TRAF2 serves as a central regulator of the cellular response to stress and cytokines through the regulation of key stress-signaling cascades. Here we demonstrate that wild-type, but not RING mutant, Siah2 targets TRAF2 for ubiquitylation and degradation in vitro. Siah2 mediates equally efficient ubi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Habelhah, Hasem, Frew, Ian J., Laine, Aaron, Janes, Peter W., Relaix, Frederic, Sassoon, David, Bowtell, David D.L., Ronai, Ze’ev
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2002
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC131073/
https://ncbi.nlm.nih.gov/pubmed/12411493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf576
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