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Stress-induced decrease in TRAF2 stability is mediated by Siah2
TRAF2 serves as a central regulator of the cellular response to stress and cytokines through the regulation of key stress-signaling cascades. Here we demonstrate that wild-type, but not RING mutant, Siah2 targets TRAF2 for ubiquitylation and degradation in vitro. Siah2 mediates equally efficient ubi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC131073/ https://ncbi.nlm.nih.gov/pubmed/12411493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf576 |
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