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Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB
TRAF2 is a RING finger protein that regulates the cellular response to stress and cytokines by controlling JNK, p38 and NF-κB signaling cascades. Here, we demonstrate that TRAF2 ubiquitination is required for TNFα-induced activation of JNK but not of p38 or NF-κB. Intact RING and zinc finger domains...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2004
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1271753/ https://ncbi.nlm.nih.gov/pubmed/14713952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600044 |
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