Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1

Following ectodomain shedding, Notch-1 undergoes presenilin (PS)-dependent constitutive intramembranous endoproteolysis at site-3. This cleavage is similar to the PS-dependent γ-secretase cleavage of the β-amyloid precursor protein (βAPP). However, topological differences in cleavage resulting in am...

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Autores principales: Okochi, Masayasu, Steiner, Harald, Fukumori, Akio, Tanii, Hisashi, Tomita, Taisuke, Tanaka, Toshihisa, Iwatsubo, Takeshi, Kudo, Takashi, Takeda, Masatoshi, Haass, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2002
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC129073/
https://ncbi.nlm.nih.gov/pubmed/12374741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf541
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