Human CRB2 Inhibits γ-Secretase Cleavage of Amyloid Precursor Protein by Binding to the Presenilin Complex

Drosophila Crumbs has been reported to attenuate Notch signaling by inhibition of γ-secretase cleavage at the wing margins. γ-Secretase is an intramembrane protease that is responsible for the generation of amyloid-β (Aβ) peptides from the β-amyloid precursor protein (APP). Here, we re-examined γ-se...

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Główni autorzy: Mitsuishi, Yachiyo, Hasegawa, Hiroshi, Matsuo, Akinori, Araki, Wataru, Suzuki, Toshiharu, Tagami, Shinji, Okochi, Masayasu, Takeda, Masatoshi, Roepman, Ronald, Nishimura, Masaki
Format: Artigo
Język:Inglês
Wydane: American Society for Biochemistry and Molecular Biology 2010
Hasła przedmiotowe:
Molecular Bases of Disease
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865292/
https://ncbi.nlm.nih.gov/pubmed/20299451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038760
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